Interview with Dr Stephanie E Combs, Heidelberg University Hospital, about the Phase-II Trial Evaluating Carbon Ion Radiotherapy for the Treatment of Primary Glioblastoma (CLEOPATRA)
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Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): early treatment results and study concepts
BACKGROUND Particle irradiation was established at the University of Heidelberg 2 years ago. To date, more than 400 patients have been treated including patients with primary brain tumors. In malignant glioma (WHO IV) patients, two clinical trials have been set up-one investigating the benefit of a carbon ion (18 GyE) vs. a proton boost (10 GyE) in addition to photon radiotherapy (50 Gy), the o...
متن کاملIn vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells
BACKGROUND To evaluate the cytotoxic effect of carbon ion radiotherapy and chemotherapy in glioblastoma cells in vitro. METHODS AND MATERIALS The human glioblastoma (GBM) cell line U87 was irradiated with photon radiotherapy (RT) doses of 2 Gy, 4 Gy and 6 Gy. Likewise, irradiation with carbon ions was performed with single carbon doses of 0.125, 0.5, 2 and 3 Gy. Four chemotherapeutic substanc...
متن کاملDosimetric Comparison between 6MV Flattened Filter and Flattening Filter Free Photon Beams in the Treatment of Glioblastoma with IMRT Technique: A Treatment Planning Study
Introduction: The present study evaluated the dosimetric comparison between 6MV flattened filter (FF) and flattening filter-free (FFF) photon beams in intensity-modulated radiation therapy (IMRT) technique for the treatment of glioblastoma (GBM) patients. Material and Methods: The present study was conducted on 10 patients with GBM previously...
متن کاملClinical outcome after particle therapy for meningiomas of the skull base: toxicity and local control in patients treated with active rasterscanning
BACKGROUND Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. In this analysis we evaluate the outcome of 110 ...
متن کاملDoes age really matter? Radiotherapy in elderly patients with glioblastoma, the Munich experience
BACKGROUND Glioblastoma is usually diagnosed around the age of 60-70 years. Patients older than 65 years are frequently described as "elderly". Several trials with monotherapy have established treatment regimens that offer therapies with reduced side effects but reduced efficacy. We analysed the outcome of elderly glioblastoma patients treated at our facility. METHODS We performed a retrospec...
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